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Evolution of disease modifying therapy clinical trial design and therapeutic endpoints for Parkinson's disease

News SAGE Publications: Journal of Parkinson’s Disease: Table of Contents Feb. 8, 2026

prTMS as an Intervention for Bradykinesia in Parkinson's Disease

Trial N/A Recruiting Feb. 8, 2026

Effect of Repetitive Bihemispheric Anodal Transcranial Direct Current Stimulation on Motor Function of Patients With Parkinson's Disease

Trial Phase 3 Not yet recruiting Feb. 8, 2026

18F-DOPA II - PET Imaging Optimization

Trial Phase 3 Recruiting Feb. 8, 2026

Association Between a 1-Year Group-Based Telerehabilitation Program and the Quality of Life of People With Parkinson's Disease: An Observational Study.

Research Archives of physical medicine and rehabilitation Feb. 8, 2026

Predictive factors of global cognitive impairment in de novo Parkinson disease with normal cognition at baseline: a 10-year cohort study.

Research Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology Feb. 6, 2026

Language skills in Parkinson's disease: state of the art.

Research Dementia & neuropsychologia Feb. 6, 2026

Optimized cortical EEG modeling for Parkinson disease diagnosis with snow Shepherd Stride tuning mechanism.

Research Cognitive neurodynamics Feb. 6, 2026

Study on Artificial Intelligence-Based Facial and Speech-Related Patterns in Parkinson's Disease and Their Digital Biomarkers

Trial N/A Recruiting Feb. 5, 2026

Medico-economic Evaluation Rehabilitation by Serious Games at Home for the Management of Patients With Parkinson's Disease Suffering From Gait and Balance Disorders

Trial N/A Recruiting Feb. 5, 2026

Effects of Directional Subthalamic Deep Brain Stimulation on Gait and Balance in Parkinson's Disease Patients

Trial N/A Completed Feb. 5, 2026

In vitro-prepared A30P alpha-synuclein fibrils adopt the conserved and disease-relevant Greek key fold.

Research bioRxiv : the preprint server for biology Feb. 5, 2026

Unexpected 123 I FP-CIT (DaT SCAN) Uptake in Palpebral Conjunctival Melanoma.

Research Clinical nuclear medicine Feb. 5, 2026

Conservative Iron Chelation as a Disease-modifying Strategy in Parkinson's Disease

Trial Phase 2 Completed Feb. 4, 2026

Moderate Versus High Volume Light-Moderate Intensity Exercise for People With Moderate Parkinson's Disease

Trial N/A Recruiting Feb. 4, 2026

Evaluation of the Effects of Aquatic Therapy on Activities of Daily Living, Walking, Balance, Posture, Pain, and Depression in Parkinson's Patients

Trial N/A Recruiting Feb. 4, 2026

Research Study for Patients With Neurological Diseases Which Evaluates the Patient Experience of the MemorEM Device

Trial N/A Enrolling by invitation Feb. 4, 2026

PRKN activation for mitophagy requires an NME3-regulated phosphatidic acid signal that separates mitochondria from endoplasmic reticulum tethering.

Research Autophagy Feb. 4, 2026

A randomized safety and feasibility crossover trial of two Mediterranean-ketogenic interventions in individuals with Parkinson's disease.

Research Journal of Parkinson's disease Feb. 4, 2026

Seasonal Depression, Depression, and Parkinson’s Disease

News A Closer Look Archives | American Parkinson Disease Association Feb. 3, 2026